TABLE 4.
Cethromycin concentrations in plasma, ELF, and AC at the time of bronchoscopy in the 300-mg-dose group (n = 35)a
| BAL time (h) | Plasma Cmax (μg/ml)b | Plasma concn (μg/ml)c | AC concn (μg/ml)c | ELF concn (μg/ml)c |
|---|---|---|---|---|
| 2 | 0.39 ± 0.09 | 0.25 ± 0.15 | 22.6 ± 12.4 | 2.5 ± 1.6 |
| 4 | 0.52 ± 0.23 | 0.38 ± 0.21 | 48.5 ± 33.0 | 2.7 ± 2.0 |
| 6 | 0.47 ± 0.13 | 0.18 ± 0.07 | 55.4 ± 38.7 | 1.6 ± 0.8 |
| 8 | 0.43 ± 0.17 | 0.09 ± 0.03 | 22.6 ± 8.9 | 0.9 ± 0.8 |
| 12 | 0.61 ± 0.21 | 0.10 ± 0.06 | 33.6 ± 17.8 | 0.8 ± 0.4 |
| 24 | 0.52 ± 0.17 | 0.01 ± 0.01 | 6.7 ± 3.4 | 0.1 ± 0.1 |
| 48 | 0.56 ± 0.14 | 0.00 ± 0.0 | 3.7 ± 4.9 | 0.0 ± 0.0 |
a
Data are given as means±SD.
b
There were no significant differences among the plasma Cmaxs (P > 0.05).
c
AC concentrations were significantly higher than ELF or plasma concentrations at 2, 4, 8, 12, 24, and 48 h (P < 0.05). ELF concentrations were significantly higher than plasma concentrations at 2, 6, 12, and 24 h (P < 0.05) but not at 4 h (P = 0.057), 8 h (P = 0.074), or 48 h (P = 0.69).