TABLE 5.
Plasma pharmacokinetic parameters in the 150- and 300-mg-dose groups
| Dose group | Parameter
|
||||||
|---|---|---|---|---|---|---|---|
| Cmax (μg/ml) | Tmax (h) | Cmin (μg/ml) | AUC0-24 (μg · hr/ml) | t1/2 (h) | Vz (liters)a | Vss (liters)b | |
| 150 mg | 0.181 ± 0.084 | 2.01 ± 1.30 | 0.004 ± 0.004 | 0.902 ± 0.469 | 4.85 ± 1.10 | 1,433 ± 843 | 1,453 ± 997 |
| 300 mg | 0.500 ± 0.168 | 2.09 ± 0.03 | 0.014 ± 0.008 | 3.067 ± 1.205 | 4.94 ± 0.66 | 761 ± 293 | 769 ± 272 |
a
Vz, volume of distribution at the terminal elimination phase.
b
Vss, volume of distribution at steady state.