TABLE 6.
Plasma pharmacodynamic parameters
| Organism (MIC90) |
Cmax/MIC90 ratio for dose group:
|
AUC/MIC90 ratio for dose group:
|
%T > MIC90 for dose group:
|
|||
|---|---|---|---|---|---|---|
| 150 mg | 300 mg | 150 mg | 300 mg | 150 mg | 300 mg | |
| M. pneumoniaea (≤0.001 μg/ml) | 184 | 504 | 906 | 3,064 | 100 | 100 |
| S. pneumoniae (0.008 μg/ml) | 23 | 63 | 113 | 383 | 78 | 100 |
| C. pneumoniae (0.015 μg/ml) | 12 | 33 | 60 | 204 | 59 | 100 |
| M. catarrhalis (0.12 μg/ml) | 2 | 4 | 8 | 25 | 10 | 39 |
| H. influenzae (4 μg/ml) | 0.05 | 0.13 | 0.23 | 0.77 | 0 | 0 |
a
MIC90 of 0.001 was used for the pharmacodynamic calculations.