TABLE 8.
ELF pharmacodynamic parameters
| Organism (MIC90) |
Cmax/MIC90 ratio for dose group:
|
AUC/MIC90 ratio for dose group:
|
%T > MIC90 for dose group:
|
|||
|---|---|---|---|---|---|---|
| 150 mg | 300 mg | 150 mg | 300 mg | 150 mg | 300 mg | |
| M. pneumoniaea (≤0.001 μg/ml) | 936 | 2,752 | 11,400 | 25,792 | 100 | 100 |
| S. pneumoniae (0.008 μg/ml) | 117 | 344 | 1,425 | 3,224 | 100 | 100 |
| C. pneumoniae (0.015 μg/ml) | 62 | 183 | 760 | 1,800 | 100 | 100 |
| M. catarrhalis (0.12 μg/ml) | 8 | 23 | 95 | 215 | 100 | 100 |
| H. influenzae (4 μg/ml) | 0.24 | 0.69 | 2.9 | 6 | 0 | 0 |
a
MIC90 of 0.001 was used for the pharmacodynamic calculations.