Fig 9. A schematic diagram depicting the mechanism by which the Arp2/3 complex governs adherence.

Compromised Arp2/3 function leads to impaired cell wall integrity which leads to increased expression and activation of the small GTPase RHO1. Activated Rho1 orchestrates a dramatic remodeling of the fungal cell wall, causing elevated levels of chitin (orange waves) and β-glucan (blue hexagons), consequently impairing the ability of C. albicans to adhere to a surface.