Table 2. Incidence rates of bleeding events stratified by clinical characteristics.

	No. ofevents	Patient time (years)	Events/100 patient-years(95% CI)
Total	326	17,613	1.85 (1.66–2.06)
Sex
Male	184	9224	1.99 (1.72–2.30)
Female	142	8387	1.69 (1.43–1.99)
INR target range
2.5–3.5	306	16,454	1.86 (1.66–2.08)
3.0–4.0	20	1157	1.73 (1.09–2.62)
Vitamin K antagonist
Phenprocoumon	262	13,278	1.97 (1.75–2.22)
Acenocoumarol	64	4333	1.48 (1.15–1.87)
Indication
Atrial fibrillation	241	13,162	1.83 (1.61–2.07)
Venous thrombosis	53	2702	1.96 (1.48–2.55)
Mechanical heart valves	4	351	1.14 (0.36–2.75)
Ischemic hearts disease	7	555	1.26 (0.55–2.50)
Vascular	9	433	2.08 (1.01–3.81)
Postoperative	3	105	2.86 (0.72–7.78)
Other	9	384	2.34 (1.14–4.30)