Fig 4. Arginase 1 expression in invasive K-Luc gliomas in chimeric mice.

Bone marrow transplant experiments between wild-type (WT) and CX₃CR₁^GFP mice were performed. After recovery, mice were implanted with K-Luc tumors and analyzed by histochemistry 10 days later. A) In CX₃CR₁^GFP recipient mice, microglia were identified as GFP⁺ cells that were Arg1^- and surrounded the tumor edge. B) In WT recipient mice, GFP⁺ macrophages were mostly Arg1⁺ and infiltrated into the tumor mass.