TABLE 1.
Mean pharmacokinetic parameters of posaconazole and drug-derived radioactivity
| Parameter | Posaconazole
|
Radioactivity
|
||
|---|---|---|---|---|
| Unit | Mean value (CV) in plasma | Unit | Mean value (CV) in plasma | |
| Cmax | ng/ml | 654 (19) | ng equiv/g | 1,260 (18) |
| Tmax [median (range)] | h | 9.25 (26) [10 (6-12)] | h | 11.0 (22) [10 (8-16)] |
| t1/2 | h | 20 (19) | NAb | NA |
| AUC0-24 h | ng·h/ml | 10,300 (22) | ng equiv·h/g | 21,300 (21) |
| AUCtf | ng·h/ml | 26,000 (26) | ng equiv·h/g | 48,100 (31) |
| AUCI | ng·h/ml | 26,100 (26) | NA | NA |
| tf | h | 183 (14) | h | 66 (26) |
| CL/F | Liter/h | 16.3 (30) | NA | NA |
| V/F | Liter | 465 (31) | NA | NA |
| CLR | ml/min | 0.0114 (76)a | NA | NA |
a
n = 3; remaining subjects had <3 urine concentrations above the LLOQ (25 ng/ml).
b
NA, not applicable.