TABLE 2.

Distribution of radioactivity in pooled human plasma extracts after a single oral dose of 399 mg of [¹⁴C]posaconazole to healthy human subjects

Peak	Rt (min)	m/z	Δa	% of profiled plasma radioactivity at:
				5 h	12 h	24 h
M2	23.2	263	−438	BITb	BIT	7.88
M5	29.0	1053	+352	BIT	ND	8.97
M8	32.6	877	+176	21.1	27.6	17.5
M7	33.2	424	−277	NDc	BIT	BIT
M9	38.8	877	+176	BIT	BIT	BIT
M12	39.7	717	+16	BIT	BIT	BIT
M13	40.2	717	+16	BIT	BIT	BIT
M14	40.9	717	+16	BIT	BIT	BIT
M15	41.6	717	+16	BIT	BIT	BIT
Posaconazole	42.1	701	0	78.9	72.4	65.7

^aThat is, the difference between the m/z value of the metabolite and that of posaconazole.

^bBIT, below the integration threshold of the ¹⁴C detector but detected by MS.

^cND, not detected by ¹⁴C or the MS detector.