TABLE 3.

Distribution of radioactivity in pooled human urine extracts after a single oral dose of 399 mg of [¹⁴C]posaconazole to healthy human subjects

Peak	Rt (min)	m/z	Δa	% of profiled radioactivity	% of dose (0-120 h)b
Unknown	12.0	NDe	NAf	9.38	1.24
Unknown	12.6	ND	NA	1.38	0.18
Unknown	13.7	ND	NA	15.5	2.04
Unknown	16.7	ND	NA	5.19	0.69
Unknown	18.2	ND	NA	6.37	0.84
M1	21.1	600	−101	8.20	1.08
M2	22.9	263	−438	4.57	0.60
M3	23.6	600	−101	2.63	0.35
Unknown	25.1	ND	NA	2.18	0.29
M4	26.2	305	−396	6.61	0.87
Unknown	29.8	ND	NA	1.38	0.18
M5	31.5	1053	+352	15.0	1.97
M6c	32.4	332	−369	6.75	0.89
M7	32.9	424	−277
M8	34.3	877	+176	10.7	1.41
M9d	38.5	877	+176	4.29	0.57
M10		719	+18
M11		715	+14
M12	39.6	717	+16	BITg	0.00
M13	40.1	717	+16	BIT	0.00
M14	40.9	717	+16	BIT	0.00
Posaconazole	42.1	701	0	BIT	0.00

^aThat is, the difference between the m/z of the metabolite and that of posaconazole.

^bThe percentage of the dose is the percentage of chromatographic peak integration multiplied by the fraction of the dose excreted in urine. The radioactivity excreted in subjects 1 to 8 (0 to 120 h) was 13.2% of the dose.

^cMetabolites M6 and M7 were not resolved from each other by the radiometric detector.

^dMetabolites M9, M10, and M11 were not resolved from each other by the radiometric detector.

^eND, not detected. No drug-related ion was detected by MS.

^fNA, not applicable.

^gBIT, below the integration threshold of the ¹⁴C detector but detected by MS.