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. 2016 Dec 9;14(12):e1002584. doi: 10.1371/journal.pbio.1002584

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© 2016 Gupta et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (A) Domain organization of IN. (B) Chemical structures of the ALLINIs used in this study. (C) Disruption of assembly by the ALLINIs GSK1264 and GSK002. Viral particles produced in the presence of 1,000 nM GSK1264 or GSK002 were visualized by transmission electron microscopy, and morphology was scored (see S1 Data). The p-value is the probability of obtaining the observed (or greater) differences in numbers of nonmature particles (immature, deformed, or ambiguous) between treated and nontreated samples, given the null hypothesis of no inhibitor-induced changes.