Table 3. Incidence Anytime of Symptoms of Grade 2 or Higher from Day 0 (post-challenge) to Day 8 in Inoculated Volunteers in Study RVL-CS-002.

Illness (with laboratory-confirmed infection)	Viral Titre Group
	1 TCID50	10 TCID50	100 TCID50
	N = 6 (%)	N = 6 (%)	N = 5 (%)
Any symptom—Grade 2 or higher	2 (33.3)	4 (66.7)	2 (40.0)
URT- Grade 2 or higher	2 (33.3)	4 (66.7)	2 (40.0)
LRT- Grade 2 or higher	1 (16.7)	0	1 (20.0)
SRT—Grade 2 or higher	0	2 (33.3)	0

URT, Upper Respiratory Tract symptoms based any 1 of the following on 2 consecutive days, at least 1 Day of which must attain Grade 2 severity, or if any of the following attain Grade 3 severity once (in conjunction with the physician’s directed physical examination) to correlate findings: rhinorrhea (runny nose), nasal congestion (stuffy nose), sneezing, sore throat.

LRT, Lower Respiratory Tract symptoms based any 1 of the following on 2 consecutive days, at least 1 Day of which must attain Grade 2 severity, or if any of the following attain Grade 3 severity once: self-reported symptom of cough and/or physician findings of new wheezes, râles, rhonchi or other lower respiratory tract signs.

SRT, Systemic Respiratory Tract symptoms based on any 1 of the following on 2 consecutive days, at least 1 Day of which must attain Grade 2 severity, or if any of the following attain Grade 3 severity once: headache persisting for >1 hour, myalgia and/or arthralgia, general malaise, chilliness/fever.