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. 2016 Dec 9;11(12):e0166940. doi: 10.1371/journal.pone.0166940

Fig 2. Predicted miR-125b downstream target genes in PE placentas.

Fig 2

The mRNA levels of ZNF543 (A), IRF4 (B), SGPL1 (C) and HIF1AN (D) was detected using Real-time qPCR in placentas derived from PE patients and the controls. Protein expression of SGPL1 is reduced in both basal (E) and chorionic plates (F) preeclamptic placentas. (G) Immunohistochemistry assay was performed in paraffin sections of human placenta to show the localization of sphingosine-1-phosphate lyase 1 (SGPL1), arrows indicate trophoblast cells. Results are presented as mean ± SEM. Statistical comparison between miR-125b mimics (or inhibitor) and the corresponding NC was performed using SPSS, with p<0.05 considered as significant. *p < 0.05, **p < 0.01.