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. 2016 Nov 30;3:16025. doi: 10.1038/mto.2016.25

Figure 2.

Figure 2

Boosting with VGX-3100 augments interferon-γ production. (a) Box and whisker plots show Interferon-γ ELISpot responses against VGX-3100 antigens after discharge from HPV001, on the day of entry into HPV002 and following the boost of VGX-3100 administered in HPV002. Bars indicate minimum and maximum values observed, lines within the box indicate median response, plus signs indicate mean response. (b) Representative staining of Interferon-γ, tumor necrosis factor-α, CD107a, Granzyme B and Perforin expression (left panels) as well as cumulative Interferon-γ production from the CD4+ and CD8+ T cell compartments across the study pre- and postboost (right panel). (c) Individual patient data for contribution of Interferon-γ production from CD4+ and CD8+ T cells. HPV, Human Papillomavirus.