Figure 3.

Boosting with VGX-3100 augments production of cytokines and lytic proteins associated with cytotoxicity. (a) Cumulative TNFα production from the CD4+ and CD8+ T cell compartments across the study population pre- and postboost. (b) Individual patient data for contribution of TNFα production from CD4+ and CD8+ T cells. (c) Cumulative cytokine and lytic protein production from the CD8+ T cell compartment across the study population pre- and post-boost, where “Cyt” stands for “Cytokine” being either IFNγ or TNFα. (d) Individual patient data for cytokine and lytic protein production from the CD8+ T cell compartment.