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. 2016 Nov 30;3:16025. doi: 10.1038/mto.2016.25

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Genes associated with inflammatory, cytotoxic and effector responses are regulated in an antigen-specific manner in PBMCs after boosting with VGX-3100. A heatmap showing individual patient responses for eight gene transcripts differentially regulated upon antigenic stimulation. A color key for upregulation or downregulation of a given transcript is included where green indicates downregulation of a transcript and red indicates upregulation. Black coloring indicates no change based on antigen stimulation. HPRT1 is has been included as a control housekeeping gene.