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. 2016 Dec 9;11(12):e0167440. doi: 10.1371/journal.pone.0167440

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© 2016 Leber et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — Simulated time course effects of LANCL2 knockout on H. pylori burden (A), macrophages and cytokines (B), and lamina propria T cells (C). Bacterial re-isolation of H. pylori from stomachs of wild-type (black), LANCL2-/- (green), LANCL2fl/fl; LysCre- (blue) and LANCL2fl/fl; LysCre+ (orange) mice at week three post-infection (D). Percentage of IL10+ CX3CR1+ CD64+ MHCII+ CD11b+ F4/80^hi macrophages (E) and IL10+ FOXP3- PD1^hi type 1 regulatory T cells (F) at week 3 post-infection in wild-type, LANCL2-/-, LANCL2fl/fl; LysCre-, and LANCL2fl/fl; LysCre+ mice. p-values less than 0.05 are considered significant and marked by an asterisk (*) for genotype differences and a pound sign (#) for treatment differences within genotype, (n = 7).