Table 2. Relative cardiac expression of wildtype and mutant Tnnt2 mRNA.
Wildtype / Total Tnnt2 mRNA | Mutant / Total Tnnt2 mRNA | |
---|---|---|
Tnnt2+/+ (WT) | 1.00 ± 0.04 | 0.00 ± 0.00 † |
TGWT | 1.24 ± 0.09 | 0.00 ± 0.00 † |
Pln-/- | 1.16 ± 0.15 | 0.00 ± 0.00 † |
Tnnt2R141W/+ | 0.55 ± 0.03 * | 0.62 ± 0.03 * |
Tnnt2R141W/+/TGWT | 1.17 ± 0.05 † | 0.17 ± 0.01 *,† |
Tnnt2R141W/+/Pln-/- | 0.44 ± 0.07 * | 0.49 ± 0.03 * |
Tnnt2R141W/R141W | 0.00 ± 0.00 *,† | 1.00 ± 0.08 *,† |
n = 4 / group.
* P<0.001 versus wildtype
† P<0.001 versus Tnnt2R141W/+.