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. 2016 Dec 9;11(12):e0167756. doi: 10.1371/journal.pone.0167756

Table 3. Factors associated with malignancy of thyroid nodule with architectural before and after reclassification.

Present classification P-value After reclassification P-value
Benign Malignant Benign NIFTPs Malignant
No. of nodules 225 (59) 159 (41) 225 (59) 39 (10) 120 (31)
Size (cm) 2.4 (1.7–3.4) 2.5 (1.7–3.6) 0.527* 2.4 (1.7–3.4) 2.3 (1.4–3.1) 2.7 (1.8–3.6) 0.089
CNB diagnoses 0.006 0.003§
 AUS-A 131 (58) 69 (43) 131 (58) 19 (49) 50 (42)
 FN/SFN 94 (42) 90 (57) 94 (42) 20 (51) 70 (58)
Presence of malignant US features <0.001 <0.001§
 Yes 81 (36) 85 (53) 81 (36) 20 (51) 65 (54)
Nuclear atypia <0.001 <0.001§
 yes 8 (4) 36 (23) 8 (4) 15 (38) 21 (18)

NIFTP, non-invasive follicular thyroid neoplasm with papillary-like nuclear features. CNB, core needle biopsy; AUS-A, atypia of undetermined significant with architectural atypia; FN/SFN, follicular neoplasm/suspicious for a follicular neoplasm;US, ultrasonography. Variables were presented as number with percentages.

*P value was estimated by Wilcoxon signed-rank test.

P value was estimated by Chi-square test.

P value was estimated by Kruskal-Wallis test.

§P value was estimated by Cochran-Armitage trend test.