Fig 9.

 Survival curves of WI-38 human diploid fibroblasts transfected with either the PLXSN control vector (▪) or the PLXSN/SPARC vector (•) after exposures to cytotoxic stresses with tert-butylhydroperoxide (t-BHP) (A) and H₂O₂ (B). Cells plated in multiwell dishes at 25 000 cells/cm² were exposed to a stress of 2 hours with increasing concentrations of t-BHP or H₂O₂ diluted in basal medium Eagle. Survival was determined at 24 hours after stress. Results are expressed as percentages of the protein content of control cells (no stressor), considered as 100 %. The results represent the mean value of 4 experiments ± SD