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. 2016 Dec 9;11(12):e0167964. doi: 10.1371/journal.pone.0167964

Fig 1. Bone phenotype and characteristics of Mcpt4-/- female mice.

Fig 1

A) Femur diaphyseal total cross sectional area (Total area), endocortical circumference, cortical thickness and total mineral content of Mcpt4-/- females and wt controls, as determined by peripheral quantitative computed tomography (pQCT). The age and number of analysed animals were 4 months (wt, n = 9; Mcpt4-/-, n = 6), 7 (wt, n = 6; Mcpt4-/-, n = 5) and 12 (wt, n = 4; Mcpt4-/-, n = 9) months (mo) old. B) Femur metaphyseal parameters as described in (A). C) Body weight of Mcpt4-/- females and wt controls at the age of 7 (wt, n = 12; Mcpt4-/-, n = 10) and 12 months (wt, n = 12; Mcpt4-/-, n = 20). D) Serum levels of P1NP (procollagen type 1 amino-terminal propeptide) and CTX-1 (C-terminal telopeptides of type I collagen), as determined by ELISA analysis (wt, n = 12; Mcpt4-/-, n = 12). Results are given as means ± SD. p < 0.05 *, p < 0.01 ** and p < 0.001 *** vs. wt.