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. 2016 Dec 9;11(12):e0168065. doi: 10.1371/journal.pone.0168065

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© 2016 Chung et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — ApoE^-/- mice were evaluated following normal cage activity (Sedentary), two weeks of wheel running in combination with saline or simvastatin (20 mg/kg) (Novel), or two weeks of wheel running in combination with saline or simvastatin after two weeks of exercise training (Accustomed). (A) Cholesterol level at the end of the intervention, (B) running wheel distance for novel exercise group, (C) running wheel distance for accustomed group, (D) grip strength, and (E) change in grip strength from beginning to end of study. E: ApoE^-/-, Z: Zocor (simvastatin), S: Saline, S: Sedentary, N: Novel, A: Accustomed. Means ± SD; n = 8-10/group. † = main effect of statin, p<0.05; ^# = statin x time interaction, p<0.05; * = within group pairwise comparison, p<0.05.