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. 2016 Dec 9;11(12):e0168065. doi: 10.1371/journal.pone.0168065

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© 2016 Chung et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — The sciatic nerve of ApoE^-/- mice was stimulated and hindlimb isometric force was evaluated following normal cage activity (Sedentary), two weeks of wheel running in combination with saline or simvastatin (20 mg/kg) (Novel), or two weeks of wheel running in combination with saline or simvastatin after two weeks of exercise training (Accustomed). (A) Maximal isometric force, (B) maximal isometric force produced with repeated stimulation to provide a measure of fatigability, (C) difference in force between initial stimulation and after 10 events to provide a measure of fatigability. E: ApoE^-/-, Z: Zocor (simvastatin), S: Saline, S: Sedentary, N: Novel, A: Accustomed. Means ± SD; n = 8-10/group. † = main effect of statin, p<0.05; ^# = time main effect, p<0.05; * = within group pairwise comparison, p<0.05.