Table 5. Associations among Time to Enucleation and High-Risk Histopathologic (HRH) Features and Treatment Group.

HRH Feature	Primary Enucleation Eyes					Secondary Enucleation Eyes
		Time to enucleation^a (days)					Time to enucleation^a (days)

	n	Median	Range	Mean (SD)	P-value	n	Median	Range	Mean (SD)	P-value
HRH (any)
Yes	46	2	0-14	3.3 (3.2)	0.451	13	604	224-4775	918.8 (1187.7)	0.018
No	98	4	0-14	3.7 (3.0)		50	340	30-2175	474.3 (433.0)

Anterior chamber invasion
Yes	8	2	0-7	2.5 (3.0)	0.306	3	884	224-4775	1961.0 (2459.2)	0.278
No	136	4	0-14	3.6 (3.0)		60	373	30-2175	496.3 (410.2)

Iris invasion
Yes	9	0	0-7	1.4 (2.4)	0.011	4	921	224-4775	1710.3 (2069.6)	0.100
No	135	4	0-14	3.7 (3.0)		59	366	30-2175	488.5 (409.2)

Ciliary body invasion
Yes	10	2	0-7	1.9 (2.3)	0.043	8	728	308-4775	1181.1 (1467.7)	0.005
No	134	4	0-14	3.7 (3.0)		55	343	30-2175	467.6 (421.8)

Massive choroid invasion
Yes	32	3	0-14	3.3 (3.1)	0.603	4	898	492-4775	1765.5 (2018.1)	0.011
No	112	3	0-14	3.6 (3.0)		59	343	30-2175	484.7 (410.9)

Postlaminar optic nerve invasion
Yes	27	2	0-14	3.2 (3.6)	0.218	1	238	238-238	238.0 (-)	0.476
No	117	4	0-14	3.6 (2.9)		62	382	30-4775	571.3 (678.0)

Scleral invasion
Yes	18	2	0-7	2.3 (2.3)	0.055	7	604	238-1024	674.0 (288.6)	0.060
No	126	4	0-14	3.7 (3.1)		56	343	30-4775	552.5 (707.9)

Extraocular disease
Yes	5	1	0-7	2.2 (2.9)	0.285	2	758	492-1024	758.0 (376.2)	0.214
No	139	3	0-14	3.6 (3.0)		61	366	30-4775	559.7 (682.3)

Time represents the number of days from diagnosis to enucleation.