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. 2016 Dec 9;11(12):e0168266. doi: 10.1371/journal.pone.0168266

Fig 4. RNA seq identifies EZH2 as a regulator of cholangiocyte differentiation.

Fig 4

A. Heatmap of differential expression analysis of RNA sequencing data from HS, HP, iDC, NHC, IHC, and hepatocyte sequencing data. B. Ingenuity pathway analysis of the hepatocyte-specific and cholangiocyte-specific clusters. C. Heatmap of differential expression analysis of epigenetic regulators from RNA sequencing of HS, HP, iDC, NHC, IHC, and hepatocyte sequencing data. D. Analysis of the known EZH2 interactome showing an increasing number of EZH2 target genes upregulated as cholangiocyte differentiation proceeds.