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. 2016 Aug 2;10(12):2787–2800. doi: 10.1038/ismej.2016.85

Figure 6.

Figure 6

Proposed mechanism of cold adaptation regulated by prophage excision. The stable residence of CP4So in host genome is preferred at warm temperature, which ensures the function of tmRNA. H-NS silences CP4So excision by binding to the promoter of alpA and represses expression of alpA at warm temperature. Although at cold temperatures, due to the de-repression of H-NS to alpA, CP4So excises and the excision leads to the formation of subpopulation (0.1–3%) of prophage-free cells with increased attached biofilm formation for the entire population.