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. 2016 Nov 30;36(48):12117–12128. doi: 10.1523/JNEUROSCI.2146-16.2016

Figure 4.

Figure 4.

ADK deficiency in the brain results in cognitive impairment. A, Associative learning in the conditioned freezing paradigm is significantly decreased during conditioned stimulus 2 (CS2) in AdkΔbrain (n = 13) mice, compared with WT (n = 15), Nestin-Cre+/− (n = 10), and Adkfl/fl (n = 14) controls. Within AdkΔbrain mice, the percentage time freezing during CS3 and CS4 is significantly increased compared with baseline CS1 freezing. B, Contextual freezing is significantly impaired in AdkΔbrain mice (n = 13), compared with WT (n = 15), Nestin-Cre+/− (n = 10), and Adkfl/fl (n = 14) controls. Data are represented as the mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ##p < 0.01.