Figure 2.

Highlighted steps of the image-processing pipeline for the MRI and microPET scans. These steps included: (1–6) MRI images were cropped, zeroed along the anterior/posterior commissure line, and manually skull stripped; (7–8) segmented into gray and white matter probability maps; and then (9–10) averaged together to create a within study template. PET images: (11–13) followed similar preprocessing steps before registration to each animals respective MRI; (14–15) intensity normalized relative to the white matter; (16) spatially normalized to the within study template; and then (17) spatially smoothed with a 6 mm Gaussian filter.