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. 2016 Nov 30;36(48):12259–12275. doi: 10.1523/JNEUROSCI.1903-16.2016

Figure 2.

Figure 2.

Maturation of spontaneous activity in mouse V1. Representative LFP voltage traces and MUA rasters during quiet wakefulness. LFP is displayed for L4; MUA for L4 and channels 100 and 200 μm above and below L4. At P4, the cortex is mostly quiet and activity consists solely of spindle-shaped (spindle burst) oscillations that result from retinal wave activity (Colonnese and Khazipov, 2010). Spindle bursts become elongated and faster with development, becoming indistinguishable from rapid β-gamma activity by P12 (blue traces show examples). At P10, significant activity between spindle bursts is first observed as high-amplitude, low-frequency modulation (red traces show examples). This low-frequency activity increases in duration, alternating with high-frequency activity, until activity becomes continuous (no silent periods). Therefore, by P14, spontaneous activity is similar to mature (P24). Scale bar, 5 s (1.25 s for expanded traces); 500 μV (250 μV for expanded traces).