Figure 7.
Processing of the early noise is required for large masking release in auditory cortex. A, The role of A1 in across-channel CMR was tested by inactivating A1 during the early noise period (left, long; A1 inactive). Blue bar represents laser on. Middle, Single-cell example PSTHs for the normal (top, long, black line) and silenced (bottom, long; A1 inactive, teal) conditions. Right, Signal response for during long-CM masker, with (teal) and without (black) preceding A1 inactivation. B, Population mean signal response for long, and long-A1 inactive conditions (ntuned-CM = 358). C, Population signal response function. D, Population detection thresholds. Cell responses were converted into a population neurometric function from the thresholds estimated using binomial probability (p < 0.05 Bonferonni corrected). Cortical inactivation during early presentation of the noise reduced improvements in signal detection thresholds.