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. 2016 Nov 22;5:e19130. doi: 10.7554/eLife.19130

Table 2.

Amino acid levels showing consistent positive correlation with longevity traits.

For the mammalian fibroblast dataset, the number of longevity traits (out of Maximum Lifespan; Female Time to Maturity; Maximum Lifespan Residual; and Female Time to Maturity Residual) with significant positive correlation with the amino acid levels at two different cut-offs (p value.robust < 0.01 and p value.robust < 0.05) are shown. For the primate and bird fibroblast dataset, the regression was performed using primate data only, bird data only, and the pooled data of both. The regression slope p value < 0.05 are in bold.

DOI: http://dx.doi.org/10.7554/eLife.19130.013

Table 2—source data 1. Phylogenetic regression of metabolite levels against longevity traits.
Regression against (A) Adult Weight; (B) Maximum Lifespan; (C) Female Time to Maturity; (D) Maximum Lifespan Residual; and (E) Female Time to Maturity Residual. ‘coef.all’, ‘p value.all’, and ‘q value.all’ refer to the regression slope, p value, and FDR-adjusted q value using all the species. ‘p value.robust’ and ‘q value.robust’ refer to the statistics after removing the potential outlier point. ‘p value.max’ and ‘q value.max’ refer to the maximal (least significant) regression p value and q value when each one of the species was left out, one at a time. Only genes with p value.robust < 0.01 and p value.max < 0.05 are shown. (F) Top hits identified by two or more longevity traits. The p value.robust against each of the four longevity traits (ML, FTM, MLres, and FTMres) as well as adult weight (AW) are shown. These metabolites were the input for pathway enrichment analysis. Pathway enrichment analysis of metabolites showing (G) positive and (H) negative correlation with longevity traits. Enrichment was performed based on hypergeometric statistics. (I) Top hits identified by two or more longevity traits, using cut-off of p value.robust < 0.05. The p value.robust against each of the four longevity traits (ML, FTM, MLres, and FTMres) as well as adult weight (AW) are shown.
DOI: http://dx.doi.org/10.7554/eLife.19130.014
elife-19130-table2-data1.xlsx (36.2KB, xlsx)
DOI: 10.7554/eLife.19130.014

Amino acid

Mammalian fibroblasts

Primate and bird fibroblasts

No. of longevity traits (out of four) with significant correlation

Regression slope p value with species maximum lifespan

Regression slope p value with species maximum lifespan residual

p value.robust < 0.01

p value.robust < 0.05

Primates only

Birds only

Primates and birds

Primates only

Birds only

Primates and birds

arginine

3

4

3.4 × 10−2

8.6 × 10−2

3.1 × 10−2

3.8 × 10−1

1.1 × 10−2

2.1 × 10−2

glutamate

2

4

6.5 × 10−2

1.8 × 10−2

1.1 × 10−2

4.6 × 10−2

2.8 × 10−1

1.3 × 10−1

histidine

0

4

9.4 × 10−2

6.0 × 10−2

4.3 × 10−2

2.3 × 10−1

1.4 × 10−1

1.7 × 10−1

leucine

2

4

2.9 × 10−3

6.0 × 10−2

4.8 × 10−3

1.4 × 10−2

5.9 × 10−1

2.3 × 10−1

lysine

3

3

9.8 × 10−3

8.2 × 10−2

1.4 × 10−2

9.1 × 10−2

2.9 × 10−1

2.5 × 10−1

methionine

1

3

3.2 × 10−1

1.4 × 10−2

2.7 × 10−2

3.0 × 10−1

3.0 × 10−2

4.9 × 10−2

phenylalanine

1

4

9.8 × 10−3

1.2 × 10−3

2.1 × 10−4

8.2 × 10−2

1.3 × 10−1

1.2 × 10−1

proline

1

4

4.4 × 10−3

3.9 × 10−4

3.6 × 10−5

3.5 × 10−2

1.2 × 10−1

5.4 × 10−2

tryptophan

2

4

9.2 × 10−3

7.8 × 10−4

1.2 × 10−4

2.6 × 10−2

2.5 × 10−1

1.5 × 10−1

tyrosine

1

3

3.2 × 10−1

8.8 × 10−3

1.8 × 10−2

4.3 × 10−1

1.7 × 10−1

2.9 × 10−1

valine

0

3

1.2 × 10−2

5.4 × 10−3

1.0 × 10−3

2.0 × 10−1

2.8 × 10−1

3.2 × 10−1