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. Author manuscript; available in PMC: 2016 Dec 9.
Published in final edited form as: Inflamm Bowel Dis. 2009 Mar;15(3):454–462. doi: 10.1002/ibd.20737

TABLE 5.

Efficacy of Prebiotics or Synbiotics in the Prevention or Treatment in Rodent IBD Models

Author Animal Model Treatment Duration Treatment Started Before or After Colitis Induction Outcome
Madsen 1999 (n = 10)84 IL-10 KO Lactulose 4 or 8 wks Before + continued Reduction of inflammation
Videla 2001 (n = 95)73 DSS Inulin 5–14 days After Reduction of inflammation
Holma 2002 (n = 42)82 TNBS GOS 13 days Before + continued No reduction of inflammation
Cherbut 2003 (n = 34)79 TNBS FOS 2 wks Before + continued Reduction of inflammation
No reduction of inflammation with FOS
Moreau 2003 (n = 96)74 DSS Starch or FOS 7 or 14 days After Reduction of inflammation with starch
Rumi 2004 (n = 30)76 DSS Lactulose 6 days During Reduction of inflammation
Lara-Villoslada 2005 (n = 20)75 DSS Goat milk oligosaccharides 8 days After Reduction of inflammation
Camuesco 2005 (n = 30)77 TNBS Lactulose 2 wks Before + continued Reduction of inflammation
Hoentjen 2005 (n = 16)58 HLA-B27 OFI 7 wks Before + continued Reduction of inflammation
Daddaoua 2006 (n = 18)81 TNBS Goat milk oligosaccharides 4 days Before + continued Reduction of inflammation
Schultz 2004 (n = 25)83 HLA-B27 Synbiotics 8 wks Before + continued Reduction of inflammation
Osman 2006 (n = 36)70 DSS Synbiotics/OFI 2 wks Before + continued Reduction of inflammation
Daddaoua 2007 (n = 30)80 TNBS AHCC 8 days Before + continued Reduction of inflammation
Winkler 2007 (n = 10)78 DSS FOS 19 days Before and during or after Reduction of inflammation