. Author manuscript; available in PMC: 2016 Dec 9.

Published in final edited form as: Org Lett. 2016 Sep 6;18(18):4466–4469. doi: 10.1021/acs.orglett.6b01938

Table 1.

Rate Constants for the Cycloaddition of Diazoacetamide 1 (R = Bn) with Alkynes 3a and 3b and with ONDs 4a and 4b^a

	R¹	R²	k (10⁻² M⁻¹s⁻¹)^a
3a	CO₂Et	CF₃	53
3b	CO₂Me	CO₂Me	0.46
4a	CO₂Et	CF₃	1.5
4b	CO₂Me	CO₂Me	1.1

Values were determined in methanol with ¹H NMR spectroscopy or ultraviolet spectroscopy.