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P. falciparum SCID mouse in vivo efficacy data. DSM421 was dosed QD for 4 days starting 3 days post infection. A. Blood parasitemia levels versus days post infection, with the indicated dose levels administered in mg/kg. The lower limit of detection was 0.01% parasitemia. B. Blood concentrations (μg/mL) of DSM421 from 0.25 – 24 h after the first dose.
