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. Author manuscript; available in PMC: 2016 Dec 10.
Published in final edited form as: ACS Infect Dis. 2016 Oct 4;2(12):945–957. doi: 10.1021/acsinfecdis.6b00144

Table 2.

Comparative kinetic analysis of DSM265 and DSM421 on a panel of P. falciparum and mammalian DHODHs.

Compd DSM265 DSM421
DHODH IC50 (μM)
P. falciparum 0.00891 0.0531
P. vivax 0.0271 0.0941
P. cynomolgi 0.0122 0.012 (0.011 – 0.014)
P. berghei 2.52 5.0 (3.5 – 7.1)
Human ~ 1002 > 100
Mouse 2.33 18 (15 – 20)
Rat 2.73 22 (18 – 26)
Dog 163 35 (31 – 39)
Rabbit > 1002 > 100
Minipig ~ 1002 > 100
Monkey ~ 1002 > 100
1

data were taken from Table 1.

2

data were taken from 18.

3

data were taken from 43.

Triplicate data were collected for each concentration in the dose response curves and error in parenthesis represents the 95% confidence interval of the fit.