Table 1.

p53 pathway SNPs and diabetes

Gene	SNP (Allele)	MAF*	Relationship with p53	Impact	References
TP53	rs1042522 (C>G)	0.46(C)		G allele (Arg72) is a risk factor for obesity and diabetes	(Bitti et al. 2011; Bonfigli et al. 2013; Burgdorf et al. 2011; Gaulton et al. 2008; Gloria-Bottini et al. 2011; Qu et al. 2011; Reiling et al. 2012; Spitsina et al. 2007)
TP53	rs17880847 (A>T)	0.01(T)		T allele predisposes to uremic complications in diabetic patients	(Szoke et al. 2009)
TCF7L2	rs7903146 (C>T)	0.23(T)	Transcription factor and transcriptional target	T allele is a risk factor for diabetes in Caucasians	(Florez 2007)
P53INP1	rs896854 (T>C)	0.48(T)	Transcriptional target	C allele is a risk factor for diabetes	(Voight et al. 2010)
ATM	rs11212617 (C>A)	0.47(A)	Activator	Regulates treatment response to metformin	(GoDarts et al. 2011)

^*Source: Genome 1000 project database (1000genomes.org)

SNP, Single Nucleotide Polymorphism; MAF, Minor Allele Frequency.