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. Author manuscript; available in PMC: 2017 Nov 15.
Published in final edited form as: Acc Chem Res. 2016 Oct 26;49(11):2509–2517. doi: 10.1021/acs.accounts.6b00414

Figure 1. The PBGS catalyzed reaction.

Figure 1

The chemically identical substrates 5-aminolevulinic acid (ALA) are named for their fate in the product porphobilinogen. A-side ALA yields the amino nitrogen and the acetic acid side chain. P-side ALA yields the pyrrole nitrogen and the propionyl side chain.