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. Author manuscript; available in PMC: 2017 Nov 15.
Published in final edited form as: Acc Chem Res. 2016 Oct 26;49(11):2509–2517. doi: 10.1021/acs.accounts.6b00414

Figure 3. Maintenance of the human PBGS structure.

Figure 3

(a) The important players in human PBGS octamer stabilization. Each interaction is essential for maintenance of the octamer. P-side ALA is shown as the Schiff base intermediate. A-side ALA is shown as a bidentate ligand to the essential active-site Zn2+. (b) Native PAGE illustrates how chelation of Zn2+ destabilizes the product-bound human PBGS octamer and hexamer accumulates with time.