Table 2.
Association between log plasma tau and abnormal amyloid and neurodegeneration imaging biomarkers
| Log Plasma tau (pg/mL) | Model 1 | Model 2 | Model 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | OR (95% CI) | P value | N | OR (95% CI) | P value | N | OR (95% CI) | P value | ||
| Abnormal PiB-PET (SUVR>1.40) | ||||||||||
| Continuous Quartiles | 536 | 1.73 (1.10–2.72) | .017 | 536 | 1.38 (0.85–2.24) | .188 | 524 | 1.54 (0.93–2.55) | .093 | |
| 1 | 536 | Reference | 536 | Reference | 524 | Reference | ||||
| 2 | 1.42 (0.87–2.31) | .159 | 1.30 (0.77–2.17) | .324 | 1.33 (0.78–2.28) | .295 | ||||
| 3 | 1.28 (0.79–2.07) | .324 | 1.04 (0.62–1.75) | .882 | 1.04 (0.61–1.78) | .875 | ||||
| 4 | 1.80 (1.10–2.96) | .020 | 1.38 (0.81–2.36) | .234 | 1.37 (0.76–2.46) | .289 | ||||
| Abnormal Hippocampal volume (<2.40 cm3) | ||||||||||
| Continuous Quartiles | 534 | 1.25 (0.76–2.07) | .379 | 534 | 1.00 (0.58–1.71) | .992 | 522 | 1.15 (0.66–2.00) | .632 | |
| 1 | 534 | Reference | 534 | Reference | 522 | Reference | ||||
| 2 | 1.00 (0.57–1.75) | 1.000 | 0.88 (0.49–1.61) | .689 | 0.95 (0.51–1.77) | .860 | ||||
| 3 | 1.16 (0.67–2.01) | .599 | 1.02 (0.56–1.84) | .948 | 1.06 (0.57–1.96) | .850 | ||||
| 4 | 1.30 (0.75–2.25) | .344 | 1.05 (0.58–1.91) | .868 | 0.86 (0.45–1.66) | .655 | ||||
| Abnormal cortical thickness (<2.74 mm) | ||||||||||
| Continuous Quartiles | 533 | 2.30 (1.44–3.68) | .001 | 533 | 1.80 (1.11–2.94) | .018 | 521 | 1.93 (1.17–3.19) | .010 | |
| 1 | 533 | Reference | 533 | Reference | 521 | Reference | ||||
| 2 | 1.40 (0.85–2.32) | .187 | 1.29 (0.76–2.18) | .348 | 1.11 (0.64–1.93) | .705 | ||||
| 3 | 1.74 (1.06–2.87) | .028 | 1.45 (0.86–2.44) | .166 | 1.36 (0.80–2.34) | .260 | ||||
| 4 | 2.36 (1.43–3.88) | .001 | 1.80 (1.06–3.05) | .029 | 1.43 (0.81–2.54) | .218 | ||||
| Abnormal FDG–PET (SUVR<1.32) | ||||||||||
| Continuous Quartiles | 539 | 1.28 (0.83–1.99) | .266 | 539 | 1.10 (0.70–1.73) | .683 | 527 | 1.05 (0.65–1.69) | .843 | |
| 1 | 539 | Reference | 539 | Reference | 527 | Reference | ||||
| 2 | 1.16 (0.72–1.88) | .541 | 1.10 (0.67–1.80) | .710 | 1.00 (0.60–1.67) | .994 | ||||
| 3 | 0.76 (0.46–1.23) | .263 | 0.66 (0.40–1.09) | .107 | 0.62 (0.37–1.04) | .071 | ||||
| 4 | 1.33 (0.82–2.15) | .248 | 1.12 (0.68–1.84) | .669 | 0.89 (0.51–1.53) | .672 | ||||
Abbreviations: OR, odds ratio; CI, confidence interval; PiB-PET, Pittsburgh Compound B-positron emission tomography; SUVR, standardized uptake value ratio; FDG-PET, fluorodeoxyglucose-positron emission tomography.
Model 1 is unadjusted. Model 2 adjusted for sex, age, education, and APOE ε4. Model 3 adjusted for the variables in Model 2 and BMI, medical conditions (hypertension, diabetes, atrial fibrillation, myocardial infarction), and medications (statins, diabetes medications, Coumadin).