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. Author manuscript; available in PMC: 2018 Jan 5.
Published in final edited form as: Eur J Med Chem. 2016 Sep 10;125:130–142. doi: 10.1016/j.ejmech.2016.09.034

Scheme 1. Modifications of Kf18 (4).

Scheme 1

Reagents and conditions: a) Me3SiI, toluene, 70 °C, 4 h; (b) for 6a, 6b, 6g, ClCOOEt, ClCOOBn, or ClSO2PhpCl, DIPEA, DMAP, DMF; for 6c, triphosgene, pyridine, CH2Cl2, tBuOH, Et3N; for 6d–f, Ac2O, (CF3CO)2O or succinic anhydride, DMAP, DIPEA, DMF, rt; for 6k, 1) N,N-di Boc-N-(trifluoromethane-sulfonyl)guani-dine, Et3N, ClCH2CH2Cl, 2) CH2Cl2, TFA; for 6h, benzyl isocyanate, Et3N, CH3CN; for 6i, ethyl isocyanate, DIPEA, CH2Cl2; for 6j, trichloroacetyl isocyanate, DIPEA, CH2Cl2.