. Author manuscript; available in PMC: 2018 Jan 5.

Published in final edited form as: Eur J Med Chem. 2016 Sep 10;125:130–142. doi: 10.1016/j.ejmech.2016.09.034

Table 1.

Tetracyclic indoline Kf18 (4) selectively potentiates β-lactam antibiotics in MRSA

Entry	Antibiotic	MIC^a	MIC (+Kf18)^a,^b	Fold of potentiation
1	methicillin	128	8	16
2	amox/clav	32	4	8
3	cefazolin	128	8	16
4	meropenem	32	2	16
5	oxacillin	64	8	8
6	tetracycline	32	16	2
7	ciprofloxacin	8	4	2
8	clindamycin	256	256	1
9	erythromycin	128	128	1
10	gentamycin	256	256	1
11	streptomycin	256	256	1
12	daptomycin	256	256	1

Minimum inhibitory concentration in μg/mL in MRSA strain ATCC BAA-44.

MIC value in the presence of 20 μM of Kf18.