Table 1.
Characteristics of adults receiving lung transplants between May 2005 and June 2015, stratified by total center volume of adult lung transplants (n = 14 877)
| Variable | Valid patients, n | Center
|
p-value1 | |
|---|---|---|---|---|
| Low volume (n = 1851) | High volume (n = 13 026) | |||
| Ischemic time (h) | 14 877 | 4.83 (1.63) | 5.16 (1.70) | <0.001 |
| Male recipient | 14 877 | 1083 (59) | 7793 (60) | 0.280 |
| Male donor | 14 877 | 1109 (60) | 7842 (60) | 0.812 |
| Recipient race | 14 877 | 0.710 | ||
| White | 1540 (83) | 10 924 (84) | ||
| Black | 166 (9) | 1097 (8) | ||
| Other | 145 (8) | 1005 (8) | ||
| Donor race | 14 877 | <0.001 | ||
| White | 1180 (64) | 8000 (61) | ||
| Black | 379 (20) | 2463 (19) | ||
| Other | 292 (16) | 2563 (20) | ||
| Bilateral LTx | 14 877 | 1308 (71) | 8595 (66) | <0.001 |
| Diagnosis | 14 877 | <0.001 | ||
| PPH | 34 (2) | 226 (2) | ||
| CF | 314 (17) | 1522 (12) | ||
| IPF | 667 (36) | 5601 (43) | ||
| COPD | 540 (29) | 3363 (26) | ||
| Sarcoidosis | 55 (3) | 413 (3) | ||
| A1AD | 69 (4) | 335 (3) | ||
| Other | 172 (9) | 1566 (12) | ||
| ECMO | 14 877 | 35 (2) | 303 (2) | 0.240 |
| Mechanical ventilation | 14 877 | 92 (5) | 891 (7) | 0.002 |
| Donor infection | 14 661 | 1015 (56) | 7447 (58) | 0.064 |
| CMV matching | 13 977 | 0.004 | ||
| R−D− | 260 (15) | 2078 (17) | ||
| R+D− | 398 (22) | 2423 (20) | ||
| R−D+ | 435 (24) | 3180 (26) | ||
| R+D+ | 690 (39) | 4513 (37) | ||
| Donor cause of death | 14 877 | 0.005 | ||
| Head trauma | 928 (50) | 6043 (46) | ||
| Cerebrovascular | 628 (34) | 4613 (35) | ||
| Other | 295 (16) | 2370 (18) | ||
| Age (years) | 14 877 | 52.71 (13.95) | 55.43 (12.86) | <0.001 |
| Year of transplant | 14 877 | 2010.39 (2.85) | 2010.18 (2.82) | 0.003 |
| Creatinine (mg/dL) | 14 852 | 0.86 (0.67) | 0.85 (0.42) | 0.266 |
| BMI (kg/m2) | 14 871 | 24.83 (4.88) | 25.10 (4.57) | 0.019 |
| Final LAS | 14 871 | 45.66 (16.87) | 46.71 (17.28) | 0.014 |
| FEV1 (% predicted) | 14 531 | 35.77 (20.51) | 38.83 (20.82) | <0.001 |
| FVC (% predicted) | 14 610 | 47.24 (17.44) | 48.69 (17.50) | <0.001 |
| O2 requirement (L/min) | 14 706 | 5.08 (4.87) | 5.25 (4.94) | 0.155 |
| Six-minute walk distance (m) | 14 698 | 230.49 (132.43) | 236.20 (134.42) | 0.088 |
| Mean PAP (mmHg) | 14 017 | 27.87 (10.64) | 27.27 (10.60) | 0.026 |
| Donor age (years) | 14 877 | 32.68 (13.32) | 34.70 (14.35) | <0.001 |
| Donor PaO2 (mmHg) | 14 782 | 359.23 (152.37) | 380.48 (148.83) | <0.001 |
Data are shown as n (%) and mean (standard deviation) for continuous and categorical variables, respectively.
A1AD, α1-antitrypsin deficiency; CF, cystic fibrosis; CMV, cytomegalovirus; COPD, chronic obstructive pulmonary disease; D, donor; ECMO, extracorporeal membrane oxygenation; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; IPF, idiopathic pulmonary fibrosis; LAS, lung allocation score; LTx, lung transplantation; PAP, pulmonary artery pressure; PaO2, partial pressure of oxygen; PPH, primary pulmonary hypertension; R, recipient.
The p-value was assessed by chi-square test for categorical variables and by t-test for continuous variables.