Table 5.
Association of pro-inflammatory burden scores with prevalent peripheral arterial disease
| Model | Pro-inflammatory burden score | |||
|---|---|---|---|---|
| Odds Ratio (95% Confidence Interval)a | ||||
| 1 | 2 | ≥3 | P for trend | |
| Crude model | 1.57 (0.71, 3.45) | 0.96 (0.33, 2.78) | 3.92 (1.96, 7.85) | 0.002 |
| Age-adjusted model | 1.62 (0.73, 3.59) | 0.85 (0.29, 2.48) | 3.11 (1.52, 6.35) | 0.025 |
| Conditions-adjusted modelb | 1.79 (0.79, 4.06) | 1.01 (0.34, 2.98) | 3.65 (1.75, 7.63) | 0.008 |
| Medications-adjusted modelc | 2.13 (0.90, 5.06) | 1.30 (0.42, 3.98) | 4.29 (1.93, 9.54) | 0.004 |
| Multivariate-adjusted modeld | 2.40 (0.95, 6.07) | 1.27 (0.39, 4.15) | 3.59 (1.48, 8.71) | 0.031 |
| Multivariate-adjusted model + smoking status | 2.25 (0.87, 5.78) | 1.15 (0.35, 3.79) | 2.88 (1.17, 7.13) | 0.097 |
| Multivariate-adjusted model + smoking pack-years | 2.42 (0.93, 6.27) | 1.28 (0.38, 4.25) | 3.29 (1.33, 8.15) | 0.052 |
| Multivariate-adjusted model + CVD risk factorse | 2.87 (1.06, 7.79) | 1.31 (0.37, 4.67) | 4.88 (1.86, 12.79) | 0.013 |
aReference group = pro-inflammatory burden score of zero
bConditions-adjusted model was adjusted for MI, hypertension, CHF, COPD, diabetes status
cMedications-adjusted model was adjusted for NSAID, Aspirin, cox-II inhibitor, ACE inhibitors, loop diuretics, antidepressants
dMultivariate-adjusted models were adjusted for age, MI, hypertension, CHF, COPD, diabetes status, NSAID, Aspirin, cox-II inhibitor, ACE inhibitors, loop diuretics, antidepressants, self-rated health status, BMI, PASE score, walking speed
eCVD risk factors included systolic blood pressure, fasting blood glucose, total cholesterol and HDL