Table 3.
Allele and Genotype frequencies (VKORC1, CYP4F2, CYP2C9*2 and CYP2C9*3) of patients administered warfarin at Korle-bu Teaching Hospital in Accra
| Genetic characteristic | Frequency, % |
|---|---|
| VKORC1 (N = 96) | |
| Gene | |
| GG (wild type) | 84 (87.5) |
| GA | 12 (12.5) |
| AA | – |
| Allele | |
| G | 180 (93.8) |
| A | 12 (6.2) |
| CYP4F2 (N = 116) | |
| Gene | |
| CC (wild type) | 28 (24.1) |
| CT | 80 (69.0) |
| TT | 8 (6.9) |
| Allele | |
| C | 136 (58.6) |
| T | 96 (41.4) |
| CYP2C9*2 (N = 86) | |
| Gene | |
| CC (wild type) | 86 (100) |
| CT | – |
| TT | – |
| Allele | |
| C | 172 (100) |
| T | – |
| CYP2C9*3 (N = 84) | |
| Gene | |
| AA (wild type) | 84 (100) |
| AC | – |
| CC | – |
| Allele | |
| A | 168 (100) |
| C | – |
CYP2C9, CYP4F2 and VKORC1 were the genes genotyped. CYP2C9*2 and CYP2C9*3 were not detected. Homozygous CYP2C9*1 or heterozygous CYP2C9*1 were considered putative since we did not genotype for the rest of the other allelic variants
N number of study participants, A adenine, G guanine, C cytosine, T thymidine