Table 4.
Pharmacokinetic parameters of LMWH-ISL-SLN and ISL-Sol after intravenous administration in mice (mean value ± SD, n = 6).
| Formulation | Dose (mg/kg) | C max (μg/mL) |
AUC(0-∞)
(μg * h/mL) |
t
1/2z
(h) |
MRT (h) | Clz (L/h/kg) |
Vz
(L/kg) |
|---|---|---|---|---|---|---|---|
| LMWH-ISL-SLN | 50 | 772.56 ± 87.29 | 838.49 ± 62.37* | 6.19 ± 0.83** | 9.92 ± 0.31** | 0.28 ± 0.21** | 2.53 ± 0.24** |
| 100 | 1493.10 ± 199.46 | 1745.07 ± 138.28* | 6.88 ± 0.77** | 9.69 ± 0.57** | 0.26 ± 0.19** | 2.57 ± 0.33** | |
| 200 | 2336.24 ± 258.59 | 2555.54 ± 296.77* | 6.10 ± 0.69** | 10.85 ± 0.48** | 0.31 ± 0.32** | 2.69 ± 0.29** | |
| ISL-Sol | 50 | 1040.88 ± 98.37 | 636.68 ± 47.95 | 2.18 ± 0.17 | 1.43 ± 0.13 | 0.08 ± 0.01 | 0.25 ± 0.02 |
| 100 | 1705.84 ± 115.63 | 1041.96 ± 89.61 | 2.04 ± 0.16 | 1.36 ± 0.12 | 0.10 ± 0.02 | 0.28 ± 0.02 | |
| 200 | 2640.40 ± 178.39 | 1616.23 ± 100.55 | 1.85 ± 0.13 | 1.30 ± 0.11 | 0.12 ± 0.01 | 0.33 ± 0.03 |
*
Statistical difference from ISL-Sol group (p < 0.05).
**
Statistical difference from ISL-Sol group (p < 0.01).