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Michael reaction of 1 and 2 in different reaction solvent to form warfarin 3 and its derivative 4.
| Entry | Reaction solvent | Reaction temperature ( ° C) | Reaction time (h) | Yield (%) | Melting point ( ° C) | Product |
|---|---|---|---|---|---|---|
| 1 | [bmim]Br | RT* | 5 | 96 | 157-160 | 3 |
| 2 | [bmim]BF4 | 50 | 6 | 82 | 157-159 | 3 |
| 3 | Ammonia & H2O | Reflux | 4:30 | 80 | 155-159 | 3 |
| 4 | H2O | Reflux | 12 | 57.1 | 157-160 | 3 |
| 5 | Pyridine | Reflux | 24 | 39.4 | 159-163 | 3 |
| 6 | Solvent- free | 100 | 8 | 75 | 133-135 | 4 |
| 7 | Pyridine(Drop) | Reflux | 16 | 21 | 130-132 | 4 |
RT: Room Temperature
