Figure 4.

(A) Acid ceramidase activity of Hep G₂ cells extract treated with different concentrations of silibinin derivatives (silybin A (SA), silybin B (SB), 3-O-galloyl silybin A (SGA) and 3-O-galloyl silybin B (SGB)) determined by measurement the fluorescence (365 nm excitation/410-460 nm emission). All data are presented as mean ± SD; n=3. *Significant difference at P<0.05 compared to control group according to one-way ANOVA, followed by Tukey›s post-hoc test

(B) Log IC50 values of studied compounds for ACDase activity on Hep G₂ cell line. All data are expressed as mean ± SD. *Significant difference at P<0.05 in comparison to SGA compound