Figure 7.

Effects of resveratrol (RES) on β-Catenin/Wnt and FOXO signaling pathways in PBMCs of CAD patients. The disrupted β-Catenin/FOXO pathway in CAD patients might be due to prolonged exposure to oxidative stress, which exerts a pathogenic role in CAD. RES could increase the MnSOD enzyme activity, however it was not through the β-Catenin/FOXO pathway. The β-catenin/Wnt pathway was intact in CAD patients but was not provoked by RES. (LRP5/6, Low density lipoprotein receptor-related protein 5/6; APC, Adenomatosis polyposis coli; GSK-3β, glycogen synthase kinase-3β; CK1, Casein kinase 1; TCF/LEF, T-cell factor/lymphoid enhancer factor; FOXO, Forkhead box O; MnSOD, Manganese superoxide dismutase; PPAR-δ, Proxisome prolifrator-activated receptor delta