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. 2016 Dec 1;11:157–169. doi: 10.1016/j.redox.2016.11.013

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6. — Histological evidence of concurrent necroinflammation, reticuloendothelial iron loading and fibrosis. (A) HE (left), Perls (center) and Sirius red (right) stains illustrating concurrent hepatocyte sideronecrosis, iron accumulation in histiocytes and initial pericellular fibrosis, respectively, in young Hfe/Nrf2^-/- mice (top images). Arrows point to hepatocyte apoptotic bodies. Bottom images disclose aggregates of hemosiderin-rich non-hepatocyte cells surrounded by collagen fibers in a middle-aged Hfe/Nrf2^-/- mouse. Bars=50 µm. (B) Sirius red stain for fibrosis and Perls stain for siderosis in the same liver from old Hfe^-/- and Hfe/Nrf2^-/- mice, representative of N=6–9. Bar=200 µm.