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. 2004 Jul 22;23(15):3175–3185. doi: 10.1038/sj.emboj.7600325

Figure 7.

Figure 7

Urokinase plasminogen activator is a mediator of CD95-mediated invasiveness. Invasiveness (A) and motility (B) assay of MCF7(FB) cells incubated simultaneously with 1 μg/ml of LzCD95L and 20 μg/ml anti-uPA mAb or 20 μM uPA-STOP. The anti-uPA mAb was added each day. C, control; A, anti-APO-1; IgG, control IgG. The experiments shown are representative of three independent experiments. A 3-day MTS assay was performed to control for cell viability in the presence of these reagents, and no toxicity was observed (data not shown).